Cardiovascular Surgery and Interventions 2021, Vol 8, Num 1 Page(s): 035-043
Are systemic diseases a risk factor for post-implantation syndrome? A systematic review and meta-analysis

Selen Öztürk1, Kemal Kavasoğlu1, Uğur Kısa1, Cevdet Uğur Koçoğulları1, İbrahim Öztürk2

1Department of Cardiovascular Surgery, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey
2Department of Anesthesiology and Reanimation, Göztepe Training and Research Hospital, Istanbul, Turkey

Keywords: Endovascular aneurysm repair, meta-analysis, post-implantation syndrome, systemic disease
Objectives: Endovascular aneurysm repair (EVAR) causes less perioperative morbidity versus the open surgical technique. In this review, we discuss whether systemic diseases have a role in the development of post-implantation syndrome (PIS).

Patients and methods: Literature search was performed using the PubMed, Scopus, and Web of Science electronic databases without date limitation and manually from the references of the related articles. Only English-language studies were included in which PIS developed after EVAR and systemic diseases were preoperatively recorded. The results of analysis were evaluated with random or fixed effect models according to the presence of heterogeneity (I2>25%).

Results: A total of 1,894 articles were reached. After reviewing the titles and abstracts, six articles including 947 patients which met the inclusion criteria were included in the meta-analysis. Coronary artery disease (odds ratio [OR]: 0.6, 95% confidence interval [CI]: 0.42-0.86; p=0.006), chronic obstructive pulmonary disease (OR: 0.67, 95% CI: 0.46-0.98; p=0.041), and heart failure (OR: 0.53, 95% CI: 0.31-0.92; p=0.02) increased the possibility of PIS development. The studies were heterogeneous for chronic obstructive lung disease and renal failure (I2>25%). Publication bias according to the Begg’s test was significant, except for the studies including renal failure (tau2<0.05).

Conclusion: Based on our meta-analysis, coronary artery disease, chronic obstructive pulmonary disease, and heart failure are important factors for development of PIS after EVAR.

DOI : 10.5606/e-cvsi.2021.1041