Cardiovascular Surgery and Interventions 2022, Vol 9, Num 3 Page(s): 152-158
The association of new atherosclerosis markers with coronary collaterals in chronic total occlusion patients

Nadir Emlek1, Ali Gökhan Özyıldız2, Elif Ergül1, Muhammed Mürsel Öğütveren1, Muhammet Öztürk1, Cihan Aydın3

1Department of Cardiology, Recep Tayyip Erdoğan University Faculty of Medicine, Rize, Türkiye
2Department of Cardiology, Recep Tayyip Erdoğan University Training and Research Hospital, Rize, Türkiye
3Department of Cardiology, Tekirdağ Namık Kemal University Faculty of Medicine, Tekirdağ, Türkiye

Keywords: Atherogenic index of plasma, chronic total occlusion, coronary collaterals, monocyte-lymphocyte ratio, triglyceride-glucose index
Objectives: In the present study, we investigated the relationship between mentioned markers and chronic total occlusion collateral development.

Patients and methods: A total of 243 patients (210 males, 33 females; mean age: 63.3±11.5; range, 51 to 76 years) who underwent coronary angiography due to typical chest pain or myocardial ischemia detected in noninvasive stress tests and diagnosed with ≥1 major coronary artery occlusion between January and September 2020 were included in the cross-sectional observational study. The angiographic collateral index was determined according to the Cohen-Rentrop classification. The patients were divided into two groups according to the sufficiency of collateral development: the well-developed collaterals group (n=155) and the poor-developed collaterals group (n=88).

Results: Statistically significant parameters in univariate logistic regression analysis were evaluated with multivariate (stepwise) logistic regression analysis; as a result, presence of chronic total occlusion in left anterior descending artery (odds ratio [OR]=2.447; 95% confidence interval [CI], 1.160-5.162; p=0.019), total number of occlusions (OR=3.503; 95% CI, 1.445-8.494; p=0.006), left ventricular ejection fraction (OR=1.056; 95% CI, 1.022-1.091; p=0.001), and the atherogenic index of plasma (OR=0.017; 95% CI, 1.022-1.091; p<0.001) were independently associated with well-developed collaterals. Although the triglyceride-glucose index had statistical significance in the univariate analysis, it was not detected as an independent variable in the multivariate analysis. The monocyte-lymphocyte ratio was not significant in the univariate analysis.

Conclusion: Of the new atherosclerosis markers, only the atherogenic index of plasma had an independent association with poor collateral development.

DOI : 10.5606/e-cvsi.2022.1368