Cardiovascular Surgery and Interventions 0 Page(s):
The utility of vitamin D levels in predicting the severity of coronary artery disease in obese patients

Burcu Candemir1, Betül Ayça Yamak2,3, Mustafa Candemir2

1Department of Endocrinology and Metabolism, Etlik City Hospital, Ankara, Türkiye
2Department of Cardiology, Gazi University Faculty of Medicine, Ankara, Türkiye
3Department of Cardiology, Hopa State Hospital, Artvin, Türkiye

Keywords: Coronary artery disease, obesity, SYNTAX score, vitamin D, 25(OH)D
Objectives: This study aimed to investigate the relationship between vitamin D (25-hydroxy [OH]D, 25[OH]D) levels and the severity of coronary artery disease (CAD), as measured by the SYNTAX score, in obese patients undergoing angiography for stable angina pectoris.

Patients and methods: This retrospective study included 120 obese patients (61 males, 59 females; mean age: 61.7±10.5 years) who underwent coronary angiography between May 2012 and June 2023. Obesity was defined as a body mass index >30 kg/m2. Serum vitamin D levels were measured within six months before angiography, and CAD severity was assessed using the SYNTAX score. Patients were categorized into three groups based on their SYNTAX scores: <23, 23-32, and ≥33.

Results: The 25(OH)D levels were significantly lower in the group with the highest SYNTAX scores. Multivariable regression analysis identified 25(OH)D levels as an independent predictor of the SYNTAX score (odds ratio=0.809, 95% confidence interval 0.743-0.881, p<0.001). A strong negative correlation was observed between 25(OH)D levels and SYNTAX scores (r=0.77, p<0.001). Additionally, a serum 25(OH)D level of 13.87 ng/mL could predict high SYNTAX scores with 81% sensitivity and 80.6% specificity.

Conclusion: This study demonstrates a significant association between low 25(OH)D levels and higher SYNTAX scores, indicating more severe CAD in obese individuals. Vitamin D deficiency may be an independent predictor of CAD severity in this population.

DOI : 10.5606/e-cvsi.2025.1769