Prior left ventricular systolic dysfunction is an independent predictor of in-hospital mortality in patients with COVID-19

Murat Çap; Abdurrahman Akyüz; Ferhat Işık; İsmail Tatlı; Önder Bilge; Ümit İnci; İlyas Kaya; Ali Karagöz

doi:10.5606/e-cvsi.2022.1212

Cardiovascular Surgery and Interventions 2022, Vol 9, Num 1 Page(s): 001-008

Prior left ventricular systolic dysfunction is an independent predictor of in-hospital mortality in patients with COVID-19

Murat Çap¹, Abdurrahman Akyüz¹, Ferhat Işık¹, İsmail Tatlı¹, Önder Bilge¹, Ümit İnci¹, İlyas Kaya¹, Ali Karagöz²

¹Department of Cardiology, University of Health Sciences, Diyarbakır Gazi Yaşargil Training and Research Hospital, Diyarbakır, Turkey
²Department of Cardiology, University of Health Sciences, Kartal Koşuyolu Yüksek Ihtisas Training and Research Hospital, Istanbul, Turkey

Keywords: COVID-19, in-hospital mortality, left ventricular systolic dysfunction

Objectives: This study aims to examine the effect of left ventricular systolic dysfunction (LVSD) on in-hospital mortality in patients hospitalized for novel coronavirus disease 2019 (COVID-19).

Patients and methods: Between June 2020 and December 2020, a total of 847 patients (423 males, 424 females; median age: 68 years; range, 58 to 77 years) who had echocardiography and had positive real-time reverse transcriptase-polymerase chain reaction were retrospectively analyzed. A left ventricular ejection fraction (LVEF%) of <50% was defined as LVSD.

Results: In 138 patients, LVEF was <50% and in 709 patients LVEF was >50% (non-LVSD). Of the patients with LVSD, 89 had mid-range LVEF (40 to 49%), and 49 had reduced LVEF (LVEF <40%). Intensive care unit admission (p<0.001), myocardial injury (p<0.001), and mechanical ventilation (p<0.001) were more frequent in patients with LVSD, and LVSD was found to significantly increase the risk of and in-hospital mortality (odds ratio=2.57, 95% confidence interval, 1.43-4.60, p=0.002). Among patients with LVSD, no significant difference was observed in terms of in-hospital mortality between patients with mid-range LVEF and patients with reduced LVEF.

Conclusion: Our study results showed that LVSD significantly increased the risk of in-hospital mortality in patients hospitalized for COVID-19. In addition, an increased risk of in-hospital mortality was present in both the mid-range LVEF and the reduced LVEF group, separately.

DOI : 10.5606/e-cvsi.2022.1212