A rare location for cardiac ... Aortic coarctation and desce ... Surgical treatment of an iso ... Comparison of the sternal wi ... Isolated insufficiency of th ... Esophagitis and gastritis ar ... Comparison of conventional e ... Removal of a missed guide wi ... Giant external iliac artery ... Prosthetic mitral valve dehi ... View All

Mitral valve replacement in ... Removal of a missed guide wi ... Surgical treatment of an iso ... Aortic coarctation and desce ... Comparison of conventional e ... PERSPECTIVE FROM the EDITOR ... A comparison of quality of l ... Surgery of mitral valve dise ... Isolated insufficiency of th ... Right anterior thoracotomy a ... View All

Back | Table of Contents | Full Text | PDF | Similar Articles |

Inhibitory effect of cilostazol on intimal hyperplasia and smooth muscle cell proliferation in a rabbit carotid artery anastomosis model

Uğur Karagöz¹, Çağatay Bilen², Abidin Cenk Erdal<sup>3

1</sup>Department of Pediatric Cardiac Surgery, University of Health Sciences, Van Training and Research Hospital, Van, Türkiye
²Department of Pediatric Cardiac Surgery, University of Health Sciences, Izmir Dr. Behçet Uz Pediatric Diseases and Surgery Training and Research Hospital, Izmir, Türkiye
³Department of Cardiovascular Surgery, Dokuz Eylül University Faculty of Medicine, Izmir, Türkiye

Keywords: Anastomosis, cilostazol, intimal hyperplasia, rabbit, smooth muscle cell proliferation

---

Objectives: This study aims to investigate the effect of cilostazol on intimal hyperplasia and smooth muscle cell proliferation in a rabbit carotid artery anastomosis model.

Materials and methods: A total of 16 New Zealand male rabbits weighing 2 to 3 kg were used in this study. The rabbits were divided into two groups with eight in each group as Group A and Group B. A vertical neck incision was made in an appropriate position for all group rabbits and the right carotid artery was dissected. The same artery was transected and anastomosis using 8/0 polypropylene was performed with a continuous anastomosis technique. Group A was assigned as the control group and no medication was given. Cilostazol was administrated to Group B at a dose of 25 mg/kg twice a day per oral for 21 days. At the end of Day 21, the anastomosis segments of the right carotid artery and contralateral carotid artery of all rabbits were sent to the histology laboratory for analysis. The lumen diameter, lumen area, intimal area, medial area, and intima/media area ratio were estimated.

Results: In the serial sections, the mean lumen diameter of Group B was found to be significantly higher than Group A (p=0.001). The lumen area of Group B was significantly higher than Group A (p=0.001). The section series were evaluated and the area of the intima of Group B was significantly lower than Group A (p=0.001). The medial area of Group B was significantly larger than Group A (p=0.001). The intima/media area ratio was significantly higher in Group A (p=0.001).

Conclusion: Cilostazol may be useful for preventing intimal hyperplasia and smooth muscle cell proliferation after vascular surgery.

Back | Table of Contents | Full Text | PDF | Similar Articles |