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Mehmet Eyüboğlu1, Ataç Çelik2
1Department of Cardiology, Izmir Demokrasi University School of Medicine, Izmir, Türkiye
2Department of Cardiology, Gaziosmanpaşa University School of Medicine, Tokat, Türkiye
Keywords: Diabetes mellitus, diabetic cardiomyopathy, electrocardiography, fragmented QRS, frontal plane QRS-T angle
Objectives: This study aims to investigate the association of clinical and glycemic parameters with fragmented QRS (fQRS) and frontal plane QRS-T (fQRS-T) angle in type 2 diabetes mellitus (DM) patients without a known cardiovascular disease (CVD).
Patients and methods: Between September 2020 and September 2021, a total of 414 consecutive type 2 DM patients (209 males, 205 females; mean age: 44.7±6.1 years; range, 33 to 61 years) without established CVD were included in this prospective study. The patients were divided into two groups according to presence or absence of fQRS on electrocardiography (ECG). Clinical and glycemic parameters of patients were compared based on fQRS, fQRS-T angle, and disease duration of DM.
Results: The frequency of fQRS on ECG was 22.9%. The glycated hemoglobin (HbA1c) levels were higher, and DM duration was longer in patients with fQRS compared to those without fQRS and in patients with fQRS-T angle >90° compared to patients with fQRS-T angle ≤90°. The frequency of fQRS and mean fQRS-T angle were significantly higher in patients with DM duration ≥10 years compared to those with DM duration <10 years. Multivariate analysis revealed that HbA1c and DM duration were independent predictors of both presence of fQRS on ECG (p<0.001 for both) and fQRS-T angle >90° (p<0.001 for both).
Conclusion: The fQRS and fQRS-T angle may predict hyperglycemic status and subclinical cardiovascular involvement in type 2 DM
patients without known CVDs.
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