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Gamze Gökalp1, Tuğçe Nalbant1, Emel Berksoy2, Şefika Bardak2, Şule Demir2, Gülşah Demir2, Pelin Elibol2, Alper Çiçek2, Yüksel Bıcılıoğlu2
1Department of Pediatrics, Division of Pediatric Emergency, Medicine Faculty of Izmir Katip Çelebi University, Izmir, Turkey
2Department of Pediatrics, Division of Pediatric Emergency, Izmir Tepecik Training and Research Hospital, Izmir, Turkey
Keywords: Beta-blocker poisoning, hypoglycemia, pediatric emergency
Objectives: In this study, we aimed to investigate factors which could facilitate the identification of hypoglycemia in beta-blocker (BB) intoxication cases.
Patients and methods: Between November 2020 and November 2021, a total of 136 patients (53 males, 83 females; mean age: 11.6+5.7 years; range, 2 to 17 years) who were admitted to the emergency department with BB poisoning were included in the study. The data on the cases were taken from the hospital’s automation system.
Results: The mean systolic blood pressure (SBP) was 86.2±12 mmHg, the mean heart rate (HR) was 72.9±12.2 bpm, and the mean blood glucose level (BGL) was 104.4±42.8 mg/dL. When the relationship between the HR, SBP, and BGL of the cases was examined, there was a poor positive correlation between BGL and HR (r=0.32, p<0.01). No linear correlation was detected between BGL and SBP or between BGL and toxic dose percentage (r=0.23, p=0.06 and r=0.16, p=0.05). A very strong negative correlation was found between the percentage of toxic dose and SBP, and between the toxic dose percentage and HR (r=-0.90, p<0.01 and r=-0.76, p=0.04). There was a weak positive correlation between HR and SBP (r=0.42, p=0.09).
Conclusion: We found a correlation between the decrease in HR and the decrease in BGL. Younger age, female sex, and high dose of the
drug facilitated the development of hypoglycemia.
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