A novel approach for lower extremity malperfusion in type A aortic dissection: A case report | |
DOI: 10.5606/e-cvsi.2025.1910 | |
Mustafa Seren1, Ali Bulut2 | |
1Department of Cardiovascular Surgery, Etlik City Hospital, Ankara, Türkiye 2Department of Cardiovascular Surgery, Private Practice, Antalya, Türkiye |
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Keywords: Cardiopulmonary bypass, lower extremity ischemia, type A aortic dissection, vascular surgical procedures | |
Lower extremity malperfusion (LEM) is a severe complication of type A aortic dissection, often leading to ischemia and increased
mortality. Optimal management remains debated, with limb-first and aortic dissection-first approaches under consideration.
A 53-year-old male presented with syncope and signs of type A aortic dissection extending from the ascending aorta to the iliac
bifurcation, causing dynamic LEM. To manage LEM while addressing the dissection, temporary distal perfusion was achieved using
a 10F catheter connected to the femoral artery cannulation line during surgery. A Bentall procedure with hemiarch replacement was
carried out (cardiopulmonary bypass time: 229 min). Postoperatively, the right lower extremity pulses were restored, and ischemia
resolved without sequelae. Temporary perfusion via a central catheter from the cardiopulmonary bypass line offers a simple and effective
solution to manage LEM during aortic dissection repair, potentially reducing ischemic complications. This approach may serve as a
bridge to definitive repair, particularly in time-sensitive scenarios. |
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Aortic dissection is a life-threatening condition
often complicated by branch vessel malperfusion,
causing ischemia in the central nervous system, visceral
organs, or extremities, posing significant therapeutic
challenges.[1] Malperfusion occurs in up to 40% of
cases, increasing risks of amputation, mortality, and
poor outcomes. Malperfusion is classified as static,
dynamic, or both. Dynamic malperfusion results
from hemodynamic forces where the dissection
flap obstructs a branch vessel’s orifice, while static
malperfusion arises from false lumen thrombosis
compressing the true lumen. Blood pressure control
may restore circulation in dynamic malperfusion,
but intervention is required if ineffective; static
malperfusion always necessitates intervention. Rapid
correction of malperfusion is critical, and choosing
between a limb-first or aortic dissection-first approach
impacts outcomes. Acute end-organ ischemia requires
urgent reperfusion to maximize survival.[1] However,
the optimal strategy for lower extremity malperfusion
(LEM) in dissection remains unclear, and
amputation rates may be underreported.[1] Traditional
interventions include extra-anatomic bypasses
(e.g., femoro-femoral, axillo-femoral) or surgical fenestration, while less invasive techniques such as
stent grafting and endovascular fenestration have been
used since the 1990s. This case report described a novel strategy for managing LEM in type A aortic dissection by providing temporary perfusion during dissection repair, minimizing ischemic complications. |
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CASE PRESANTATION
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A 53-year-old male presented to the emergency
department with syncope and limb pain. Physical
examination revealed left-sided ptosis and absent
pulses in the right lower extremity, which was cold
and pale. Echocardiography showed severe aortic insufficiency. Computed tomography (CT) confirmed
a DeBakey type A dissection (Figures 1a-d). At the
celiac artery origin, the false lumen dominated
the aortic cross-sectional area, with increasing
dominance distal to the renal arteries. At the
iliac bifurcation, the false lumen occupied the
entire area (Figure 1c). The left iliac artery (false
lumen-originating) showed contrast filling, but the
right common iliac, external iliac, and proximal
femoral arteries (true lumen-originating) exhibited
no contrast, indicating dynamic malperfusion
(Figure 1d). Written informed consent was obtained
from the patient.
Surgical procedure Figure 2. Postoperative computed tomography showing restored bilateral femoral perfusion. |
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Lower extremity malperfusion in acute type A
aortic dissection remains a complex clinical entity with significant prognostic implications. The therapeutic
dilemma centers around whether to prioritize
limb revascularization or central aortic repair, as
delayed perfusion can exacerbate ischemic injury,
yet postponing dissection repair may lead to fatal
complications. Plotkin et al.[1] reported increased
early failure rates in patients undergoing limb-first
interventions compared to those receiving immediate
aortic repair, while Charlton-Ouw et al.[2] noted
that one-third of LEM cases required additional
interventions after aortic surgery. In the present case, the patient exhibited dynamic malperfusion of the right lower extremity due to collapse of the true lumen at the iliac bifurcation. Arterial cannulation was achieved via the right femoral artery to access the true lumen. To preserve perfusion to the distal limb during Bentall procedure, a 10F catheter was introduced distal to the femoral cannulation site and connected to the CPB line. This allowed for simultaneous antegrade and retrograde flow during systemic circulation support, maintaining limb perfusion throughout the surgical period. This approach is conceptually related to distal perfusion techniques commonly used in extracorporeal membrane oxygenation patients to prevent limb ischemia[3] but has been adapted here to the context of acute aortic dissection surgery. The advantage of this technique lies in its simplicity, timeliness, and compatibility with emergent operative settings without the need for additional surgical exposure or delayed reperfusion. Postoperatively, the patient did not require any further intervention for the lower extremity. Ischemia resolved completely without evidence of neurologic or muscular sequelae. Although metabolic acidosis occurred transiently following reperfusion, it responded to standard medical management. These outcomes suggest that intraoperative maintenance of distal perfusion may contribute to mitigation of ischemia-reperfusion injury, an effect previously highlighted in the context of malperfusion management.[4,5] The strategy employed aligns with evolving perspectives on individualized cannulation techniques in aortic dissection. Xia et al.[6] emphasized the utility of double arterial cannulation in providing both cerebral and distal organ perfusion, particularly in complex cases with compromised true lumen flow. While our approach does not involve formal double arterial cannulation in the classic sense, the use of a temporary distal perfusion line achieves a similar goal, ensuring effective systemic and peripheral circulation during the critical phases of aortic repair. In conclusion, LEM in aortic dissection increases mortality and morbidity, and its optimal management remains unresolved. Our novel approach of temporary perfusion via a 10F catheter from the CPB line during dissection repair offers a simple, effective method to address LEM while enabling prompt dissection repair. This strategy may reduce ischemic complications in time-sensitive settings, warranting further investigation. Data Sharing Statement: The data that support the findings of this study are available from the corresponding author upon reasonable request. Author Contributions: All authors contributed equally to this article. Conflict of Interest: The authors declared no conflicts of interest with respect to the authorship and/or publication of this article. Funding: The authors received no financial support for the research and/or authorship of this article. |
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1) Plotkin A, Vares-Lum D, Magee GA, Han SM, Fleischman
F, Rowe VL. Management strategy for lower extremity
malperfusion due to acute aortic dissection. J Vasc Surg
2021;74:1143-51. doi: 10.1016/j.jvs.2021.04.032.
2) Charlton-Ouw KM, Sandhu HK, Leake SS, Jeffress K, Miller
CC Rd, Durham CA, et al. Need for limb revascularization
in patients with acute aortic dissection is associated with
mesenteric ıschemia. Ann Vasc Surg 2016;36:112-20. doi:10.1016/j.avsg.2016.03.012.
3) Makdisi G, Makdisi T, Wang IW. Use of distal
perfusion in peripheral extracorporeal membrane
oxygenation. Ann Transl Med 2017;5:103. doi: 10.21037/
atm.2017.03.01.
4) Deeb GM, Patel HJ, Williams DM. Treatment for
malperfusion syndrome in acute type A and B aortic
dissection: A long-term analysis. J Thorac Cardiovasc Surg
2010;140:S98-100. doi: 10.1016/j.jtcvs.2010.07.036.
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