| The utility of vitamin D levels in predicting the severity of coronary artery disease in obese patients | |
| DOI: 10.5606/e-cvsi.2025.1769 | |
| Burcu Candemir1, Betül Ayça Yamak2, 3, Mustafa Candemir2 | |
|
1Department of Endocrinology and Metabolism, Etlik City Hospital, Ankara, Türkiye 2Department of Cardiology, Gazi University Faculty of Medicine, Ankara, Türkiye 3Department of Cardiology, Hopa State Hospital, Artvin, Türkiye |
|
| Keywords: Coronary artery disease, obesity, SYNTAX score, vitamin D, 25(OH)D | |
Objectives: This study aimed to investigate the relationship between vitamin D (25-hydroxy [OH]D, 25[OH]D) levels and the severity of
coronary artery disease (CAD), as measured by the SYNTAX score, in obese patients undergoing angiography for stable angina pectoris. Patients and methods: This retrospective study included 120 obese patients (61 males, 59 females; mean age: 61.7±10.5 years) who underwent coronary angiography between May 2012 and June 2023. Obesity was defined as a body mass index >30 kg/m2. Serum vitamin D levels were measured within six months before angiography, and CAD severity was assessed using the SYNTAX score. Patients were categorized into three groups based on their SYNTAX scores: <23, 23-32, and ≥33. Results: The 25(OH)D levels were significantly lower in the group with the highest SYNTAX scores. Multivariable regression analysis identified 25(OH)D levels as an independent predictor of the SYNTAX score (odds ratio=0.809, 95% confidence interval 0.743-0.881, p<0.001). A strong negative correlation was observed between 25(OH)D levels and SYNTAX scores (r=0.77, p<0.001). Additionally, a serum 25(OH)D level of 13.87 ng/mL could predict high SYNTAX scores with 81% sensitivity and 80.6% specificity. Conclusion: This study demonstrates a significant association between low 25(OH)D levels and higher SYNTAX scores, indicating more severe CAD in obese individuals. Vitamin D deficiency may be an independent predictor of CAD severity in this population. |
|
